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KMID : 0438219740110021221
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Korea University Medical Journal
1974 Volume.11 No. 2 p.1221 ~ p.1234
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Experimental Study on Injection Injury of the Sciatic Nerve
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Abstract
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Serious sciatic nerve injury may result usually from erroneous injections of commonly used antibiotics and other therapeutic or prophylactic agents into the gluteal region at any age especially in infant, children and in small or debilitated patients.
Although many isolated cases and several large series have been reported the pathogenesis and pathology of injection injury in man have been poorly studied.
This experimental study was undertaken to observe histological changes following injection of various drugs such as Rheumapyrine, Chloromycetin, Penicillin, Normal saline and Distilled water to the sciatic nerve and also has attempted to clarify the pathogenesis and pathology of injection injury in normal adult rabbits weighing 1.5-2kg. Sixty-seven experimental animals were divided into 5 groups-Distilled water. Normal saline, Chloromycetin, Penicillin and Rheumapyrine injection groups.
After both sciatic nerves are exposed under the local anesthesia, agents were injected intraneurally on the right side and perineurally on the left side. Pathologic specimens were then taken at interval of 1.3, 7 and 21 days after the injection.
The results obtained are summarized as follows:
1) Rheumapyrine produced the greatest reaction. Penicillin was the next and Chloromycetin was the least damaging of the drugs in this study. Saline and Distilled water caused no damage.
2) Major pathologic changes of the injured sciatic nerve were degeneration of axon, myelin sheath and bundle atrophy in nervous tissues, and acute exudative inflammation and granulation in the soft tissues.
3) It was postulated that disability after injection injury developed in cases of severay damaged nervous tissue.
4) It was found that the major source of damage to the sciatic nerve was chemical agent which was toxic to the peripheral nerves, and the site of damage was intraneural, unless a very toxic agent was deposited near the nerve.
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